Sale!
Mary Garry, PhD
$2.00 Original price was: $2.00.$1.00Current price is: $1.00.
Mary Garry, PhD
Professor of Medicine, Cardiovascular Division
Faculty, PhD Program in Integrative Biology and Physiology
Founder & Director, LHI Summer Research Scholars Program (2008-2017), Lillehei Heart Institute
Administrator Info
Name: Lisa Moe
Email: seif0046@umn.edu
Mail: Cancer & Cardiovascular Research Building
2231 6th St SE, 1st floor Mailroom CCRB
Minneapolis, MN 55455
+
Biography
Summary
Mary Garry, Ph.D., is a Professor in the Lillehei Heart Institute at the University of Minnesota. Her laboratory has studied skeletal muscle and exercise physiology for more than twenty years, with a focus on sensory mechanisms that cause muscle fatigue and exercise intolerance in disease. Her laboratory was the first to generate models for and define the Exercise Pressor Reflex in rat and mouse. These models have been used extensively around the world to evaluate the mechanisms of abnormal cardiovascular responses to exercise in disease. More recently, Dr. Garry’s laboratory has focused on gene editing and somatic cell nuclear technologies to generate large animal research models. Specifically, her laboratory focuses on the engineering of humanized skeletal muscle in the pig. These initiatives are focused on the generation of an unlimited source of human muscle and resident stem cell populations for therapeutic initiatives in patients with muscle disorders and the generation of novel large animal research models. This approach has the potential for generating in vivo models to allow the testing of novel therapeutics and individualized patient responsiveness to established therapeutics.
+
Education
Graduate School
PhD, University of Minnesota
Fellowships
Postdoctoral Fellow, NIH NRSA, University of Minnesota, Dental School, Department of Restorative Science
+
Publications
Selected Publications
- Choe YH, Das S, Ma X, Lee H, Sorensen JR, Hoffman DB, Jo CH, Johnson CP, Cassel N, Garry DJ, Greising SM, Garry MG. Porcine myogenesis in cloned wildtype and MYF5/MYOD/MYF6-null porcine embryo. Commun Biol. 2025 Feb 11;8(1):217. doi: 10.1038/s42003-025-07648-1. PMID: 39934347; PMCID: PMC11814088.
- Garry, D. J., Zhang, J. J., Larson, T. A., Sadek, H. A., Garry, M. G. (2023). Networks that Govern Cardiomyocyte Proliferation to Facilitate Repair of the Injured Mammalian Heart. Methodist DeBakey cardiovascular journal, 19(5), 16-25. PMID: 38028968 PMCID: PMC10655759 doi: 10.14797/mdcvj.1300
- Sierra-Pagan, J. E., Dsouza, N., Das, S., Larson, T. A., Sorensen, J. R., Ma, X., Stan, P., Wanberg, E. J., Shi, X., Garry, M. G., Gong, W., Garry, D. J. (2023). FOXK1 regulates Wnt signalling to promote cardiogenesis. Cardiovascular research, 119(8), 1728-1739. PMID: 37036809 PMCID: PMC10325700 doi: 10.1093/cvr/cvad054
- Das, S., Gupta, V., Bjorge, J., Shi, X., Gong, W., Garry, M. G., Garry, D. J. (2023). ETV2 and VEZF1 interaction and regulation of the hematoendothelial lineage during embryogenesis. Frontiers in cell and developmental biology, 11, 1109648. PMID: 36923254 PMCID: PMC10009235 doi: 10.3389/fcell.2023.1109648
- Garry, D. J., Weiner, J. I., Greising, S. M., Sachs, D. H., Garry, M. G. (2023). Xenotransplantation and exotransplantation: Strategies to expand the number of donor organs. Xenotransplantation, 30(1), e12786. PMID: 36367201 doi: 10.1111/xen.12786
- Greising, S., Weiner, A., Garry, D., Sachs, D., Garry, M. (2022). Human muscle in gene edited pigs for treatment of volumetric muscle loss. Front Genet., 13(948496). PMID: 35957684 doi: 10.3389/fgene.2022.948496
+
Research
The Garry lab has two major areas of focus. The first area of focus is the neural control of cardiovascular responses to exercise. Specifically, the lab focuses on the Exercise Pressor Reflex which is a reflex activated by skeletal muscle contraction. The Garry lab has developed novel rodent models (rat and mouse) to explore the mechanisms that mediate this reflex in both physiological and pathological states. Abnormal function of this reflex occurs in a variety of diseases such as heart failure, hypertension, and diabetes and extreme abnormalities serves as a poor prognostic indicator. The goal of the lab is to identify specific mechanisms that underlie the abnormal reflex in various disease such that normalization of the reflex can be targeted with novel therapies. The second area of focus for the Garry lab is the generation of humanized organs for 1) novel human research models and 2) transplantation purposes. To that end, we have generated several models in which pigs develop humanized organs. Specifically, we have developed pigs with human skeletal muscle and pigs with human blood vessels and blood. These models will be used to generate unique research models and even allow for a new form of clinical trial without human risk. Additionally, we are developing organs for human transplantation purposes that will treat injury based deficits such as volumetric muscle loss. Moreover, these technologies can treat peripheral artery disease and can help to meet the staggering demand for human blood and platelets.Come work with us! Visit https://med.umn.edu/lhi/about/jobs to see open positions in the Mary Garry lab.
+
Awards, Honors and Recognitions
- Baccaner Award for Outstanding Graduate Studies, University of Minnesota (1990)
- Fellow, American Heart Association (2019)
- Established Investigator Award, American Heart Association (2006)
- NIH NRSA Postdoctoral Fellow, American Heart Association (1990)
+
Professional Memberships
President’s Initiative to Prevent Sexual Misconduct (PIPSM), Member
Faculty Senate, University of Minnesota, Member
Faculty Senate, Research Subcommittee, Member
Muscular Dystrophy Center, University of Minnesota, Member
Institute for Engineering and Medicine, University of Minnesota, Member
Lillehei Heart Institute, University of Minnesota, Member
Category: Uncategorized
Reviews
There are no reviews yet.